Junkman3, Diesel Dan Renovetz, built a '70 C3500 pickup decades ago with a 4-53 I believe. He has run that thing all over the country. Recently did a restore on the body.
I'd like to buy or build a Detroit powered truck myself. I think I'll stay in the medium duty range. Here is a beautiful Advance Design as well. It sits on an Isuzu or other Nippon medium straight rail chassis. He drives it to Macungie from, I believe, Ohio. That's what I want!
EDIT: I see NJ plates, so I guess it got sold. Pretty sure the firts time I saw it it came from a greater distance, which impressed me