Rear differential help please

[Woodnears]

I am asking for your help or basically telling me what I need to do to get the most out of this truck. 68 C10, currently has a 4.8 ls engine backed with a 4l60e. The rear axle is stock with 373 gears. I am running 22x9 wheels and I’m curious if I need to consider changing gear ratios but have no experience with this area.
Anyone else running a similar setup that could give some advice? It’s obviously not a speed demon but I do want a quality built rearend that will handle any future upgrades. Am I asking too much?