quadrajet on a 250 inline advice

[sixtyeightchevykid]

as the title states, i picked up an offenhauser 4 barrel intake manifold. and the guy gave me 4 quadrajets to go with the manifold. im kinda new to the carb set up and tuning. i was hoping some input on how to set up a quad to use on my inline. here is what i would like.. reliability out of this set up, better performance , and still have reasonable mileage, i would like to keep the manual choke that i have now.
any advice good or bad is welcome, thanks in advance..